Article
Mutation of SH2B3 (LNK), a genome-wide association study candidate for hypertension, attenuates Dahl salt-sensitive hypertension via inflammatory modulation.
Hypertension (Dallas, Tex. : 1979) - 1 May 2015
Rudemiller Nathan P, Lund Hayley, Priestley Jessica R C, Endres Bradley T, Prokop Jeremy W, Jacob Howard J, Geurts Aron M, Cohen Eric P, Mattson David L
Abstract excerpt
Human genome-wide association studies have linked SH2B adaptor protein 3 (SH2B3, LNK) to hypertension and renal disease, although little experimental investigation has been performed to verify a role for SH2B3 in these pathologies. SH2B3, a member of the SH2B adaptor protein family, is an intracellular adaptor protein that functions as a negative regulator in many signaling pathways, including inflammatory...
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