A Single Nucleotide Polymorphism in SH2B3/LNK Promotes Hypertension Development and Renal Damage.

doi:10.1161/CIRCRESAHA.121.320625

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Article

A Single Nucleotide Polymorphism in SH2B3/LNK Promotes Hypertension Development and Renal Damage.

Circulation research - 14 Oct 2022

Alexander Matthew R, Hank Samuel, Dale Bethany L, Himmel Lauren, Zhong Xue, Smart Charles D, Fehrenbach Daniel J, Chen Yuhan, Prabakaran Nitin, Tirado Brian, Centrella Megan, Ao Mingfang, Du Liping, Shyr Yu, Levy Daniel, Madhur Meena S

Abstract excerpt

BACKGROUND: SH2B3 (SH2B adaptor protein 3) is an adaptor protein that negatively regulates cytokine signaling and cell proliferation. A common missense single nucleotide polymorphism in SH2B3 (rs3184504) results in substitution of tryptophan (Trp) for arginine (Arg) at amino acid 262 and is a top association signal for hypertension in human genome-wide association studies. Whether this variant is causal for...

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Identifiers

PMID: 36169218
DOI: 10.1161/CIRCRESAHA.121.320625
PMCID: PMC9588739

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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