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Article

The Autoimmune Risk R262W Variant of the Adaptor SH2B3 Improves Survival in Sepsis.

Journal of immunology (Baltimore, Md. : 1950) - 1 Dec 2021

Allenspach Eric J, Shubin Nicholas J, Cerosaletti Karen, Mikacenic Carmen, Gorman Jacquelyn A, MacQuivey Matthew A, Rosen Aaron B I, Timms Andrew E, Wray-Dutra Michelle N, Niino Kerri, Liggitt Denny, Wurfel Mark M, Buckner Jane H, Piliponsky Adrian M, Rawlings David J

Abstract excerpt

The single-nucleotide polymorphism (SNP) rs3184504 is broadly associated with increased risk for multiple autoimmune and cardiovascular diseases. Although the allele is uniquely enriched in European descent, the mechanism for the widespread selective sweep is not clear. In this study, we find the rs3184504*T allele had a strong association with reduced mortality in a human sepsis cohort. The rs3184504*T allele...

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Share to Adaptor Proteins, Signal Transducing
Share to Disease Models, Animal
Share to Mice
Share to Mice, Congenic
Share to Mice, Inbred C57BL
Share to Mice, Knockout
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Share to Sepsis

Source

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Identifiers

PMID: 34740959
DOI: 10.4049/jimmunol.2100454
PMCID: PMC8612972

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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