Article
Hepatitis B virus pre-S2 mutant upregulates cyclin A expression and induces nodular proliferation of hepatocytes.
Hepatology (Baltimore, Md.) - 1 Apr 2005
Wang Hui-Ching, Chang Wen-Tsan, Chang Wen-Wei, Wu Han-Chieh, Huang Wenya, Lei Huan-Yao, Lai Ming-Derg, Fausto Nelson, Su Ih-Jen
Abstract excerpt
Naturally occurring mutants with a deletion in the pre-S2 region of the large surface protein (Delta S2-LHBs) are prevalent in serum and livers of patients with chronic hepatitis B virus (HBV) infection associated with cirrhosis. The Delta S2-LHBs protein is retained in the endoplasmic reticulum (ER) and may induce ER stress. One interesting observation is the consistently clustered distribution of hepatocytes...
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