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Article

Hepatitis B virus pre-S2 mutant upregulates cyclin A expression and induces nodular proliferation of hepatocytes.

Hepatology (Baltimore, Md.) - 1 Apr 2005

Wang Hui-Ching, Chang Wen-Tsan, Chang Wen-Wei, Wu Han-Chieh, Huang Wenya, Lei Huan-Yao, Lai Ming-Derg, Fausto Nelson, Su Ih-Jen

Abstract excerpt

Naturally occurring mutants with a deletion in the pre-S2 region of the large surface protein (Delta S2-LHBs) are prevalent in serum and livers of patients with chronic hepatitis B virus (HBV) infection associated with cirrhosis. The Delta S2-LHBs protein is retained in the endoplasmic reticulum...

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PMID: 15726643
DOI: 10.1002/hep.20615

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-15726643-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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