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Article

Epigenetic Regulation of MicroRNA Expression by Hepatitis B Virus Pre-S2 Mutant Promotes Hepatocellular Carcinoma Tumorigenesis.

Liver international : official journal of the International Association for the Study of the Liver - 1 Apr 2026

Lin Yueh-Te, Jeng Long-Bin, Shih Fu-Ying, Teng Chiao-Fang

Abstract excerpt

BACKGROUND & AIMS: Discovery of therapeutic targets for hepatocellular carcinoma (HCC) is urgently needed. As an important hepatitis B virus (HBV) oncoprotein, pre-S2 mutant activates multiple signalling pathways to induce HCC development. METHODS: This study investigated the effect of pre-S2 mutant on regulating microRNA (miRNA) expression and the role of miRNAs in mediating pre-S2 mutant's oncogenic functions....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41797438
DOI: 10.1111/liv.70582

Genes

KAT5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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