Article
Genomic instability caused by hepatitis B virus: into the hepatoma inferno.
Frontiers in bioscience (Landmark edition) - 1 Jun 2011
Hsieh Yi-Hsuan, Hsu Jye-Lin, Su Ih-Jen, Huang Wenya
Abstract excerpt
Chronic hepatitis B virus (HBV) infection is an important cause of hepatocellular carcinoma (HCC) worldwide, especially in Asia. HBV induces HCC through multiple oncogenic pathways. Hepatitis-induced hepatocyte inflammation and regeneration stimulates cell proliferation. The interplay between the...
Topics
- Carcinoma, Hepatocellular
- Cell Cycle
- DNA Damage
- DNA Repair
- Genomic Instability
- Hepatitis B virus
- Hepatitis B, Chronic
- Humans
- Liver
- Liver Neoplasms
- Models, Biological
- Mutagens
- Mutation
- Oncogene Proteins, Viral
- Oxidative Stress