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Article

Genomic instability caused by hepatitis B virus: into the hepatoma inferno.

Frontiers in bioscience (Landmark edition) - 1 Jun 2011

Hsieh Yi-Hsuan, Hsu Jye-Lin, Su Ih-Jen, Huang Wenya

Abstract excerpt

Chronic hepatitis B virus (HBV) infection is an important cause of hepatocellular carcinoma (HCC) worldwide, especially in Asia. HBV induces HCC through multiple oncogenic pathways. Hepatitis-induced hepatocyte inflammation and regeneration stimulates cell proliferation. The interplay between the viral and host factors activates oncogenic signaling pathways and triggers cell transformation. In this review, we...

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PMID: 21622197
DOI: 10.2741/3874

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