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Article

Transmembrane tethering of synaptotagmin to synaptic vesicles controls multiple modes of neurotransmitter release.

Proceedings of the National Academy of Sciences of the United States of America - 24 Mar 2015

Lee Jihye, Littleton J Troy

Abstract excerpt

Synaptotagmin 1 (Syt1) is a synaptic vesicle integral membrane protein that regulates neurotransmitter release by activating fast synchronous fusion and suppressing slower asynchronous release. The cytoplasmic C2 domains of Syt1 interact with SNAREs and plasma membrane phospholipids in a Ca(2+)-dependent manner and can substitute for full-length Syt1 in in vitro membrane fusion assays. To determine whether...

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Identifiers

PMID: 25775572
DOI: 10.1073/pnas.1420312112
PMCID: PMC4378450

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Transmembrane tethering of synaptotagmin to synaptic vesicles controls multiple modes of neurotransmitter release.PMID 25775572Read ↗

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