Article
The C(2)B Ca(2+)-binding motif of synaptotagmin is required for synaptic transmission in vivo.
Nature - 18 Jul 2002
Mackler J M, Drummond J A, Loewen C A, Robinson I M, Reist N E
Abstract excerpt
Synaptotagmin is a synaptic vesicle protein that is postulated to be the Ca(2+) sensor for fast, evoked neurotransmitter release. Deleting the gene for synaptotagmin (syt(null)) strongly suppresses synaptic transmission in every species examined, showing that synaptotagmin is central in the synaptic vesicle cycle. The cytoplasmic region of synaptotagmin contains two C(2) domains, C(2)A and C(2)B. Five, highly...
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