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Article

Differential regulation of synchronous versus asynchronous neurotransmitter release by the C2 domains of synaptotagmin 1.

Proceedings of the National Academy of Sciences of the United States of America - 17 Aug 2010

Yoshihara Motojiro, Guan Zhuo, Littleton J Troy

Abstract excerpt

Synaptic vesicle fusion at many synapses has been kinetically separated into two distinct Ca(2+)-dependent temporal components consisting of a rapid synchronous phase followed by a slower asynchronous component. Mutations in the synaptic vesicle Ca(2+) sensor Synaptotagmin 1 (Syt 1) reduce synchronous neurotransmission while enhancing the slower asynchronous phase of release. Syt 1 regulation of vesicle fusion...

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Identifiers

PMID: 20679236
DOI: 10.1073/pnas.1000606107
PMCID: PMC2930414

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Differential regulation of synchronous versus asynchronous neurotransmitter release by the C2 domains of synaptotagmin 1.PMID 20679236Read ↗

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