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Article

Negative regulation of yeast Eps15-like Arp2/3 complex activator, Pan1p, by the Hip1R-related protein, Sla2p, during endocytosis.

Molecular biology of the cell - 1 Feb 2007

Toshima Jiro, Toshima Junko Y, Duncan Mara C, Cope M Jamie T V, Sun Yidi, Martin Adam C, Anderson Scott, Yates John R, Mizuno Kensaku, Drubin David G

Abstract excerpt

Control of actin assembly nucleated by the Arp2/3 complex plays a crucial role during budding yeast endocytosis. The yeast Eps15-related Arp2/3 complex activator, Pan1p, is essential for endocytic internalization and proper actin organization. Pan1p activity is negatively regulated by Prk1 kinase phosphorylation after endocytic internalization. Phosphorylated Pan1p is probably then dephosphorylated in the...

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Identifiers

PMID: 17151356
DOI: 10.1091/mbc.e06-09-0788
PMCID: PMC1783767

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

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Negative regulation of yeast Eps15-like Arp2/3 complex activator, Pan1p, by the Hip1R-related protein, Sla2p, during endocytosis.PMID 17151356Read ↗

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A novel function of Arp2p in mediating Prk1p-specific regulation of actin and endocytosis in yeast.Semantic proximity Read ↗

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An interaction between Sla1p and Sla2p plays a role in regulating actin dynamics and endocytosis in budding yeast.Semantic proximity Read ↗

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