Article

Growth-regulated Hsp70 phosphorylation regulates stress responses and prion maintenance

2019-09-05

Abstract excerpt

Maintenance of protein homeostasis in eukaryotes during normal growth and stress conditions requires the functions of Hsp70 chaperones and associated co-chaperones. Here we investigate an evolutionarily-conserved serine phosphorylation that occurs at the site of communication between the nucleotide-binding and substrate-binding domains of Hsp70. Ser151 phosphorylation in yeast Hsp70 (Ssa1) is promoted by cyclin-de...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1927de5c-4828-5c90-9bdd-1880644849a6
DOI: 10.1101/759241

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Growth-regulated Hsp70 phosphorylation regulates stress responses and prion maintenanceDOI 10.1101/759241Read

Mutational analysis of Sse1 (Hsp110) suggests an integral role for this chaperone in yeast prion propagation in vivo.Semantic proximity Read

Hsp70 is phosphorylated in a conserved response to DNA damage and contributes to cell cycle controlSemantic proximity Read

Dissecting the Cdc37 cochaperone code: Functional roles in chaperone-mediated stress adaptation.Semantic proximity Read

The function of the yeast molecular chaperone Sse1 is mechanistically distinct from the closely related hsp70 family.Semantic proximity Read

Redox regulation of yeast Hsp70 modulates protein quality control while directly triggering an Hsf1-dependent cytoprotective responseSemantic proximity Read

Mutations in the Yeast Hsp70, Ssa1, at P417 Alter ATP Cycling, Interdomain Coupling, and Specific Chaperone Functions.Semantic proximity Read

Differential role of cytosolic Hsp70s in longevity assurance and protein quality control.Semantic proximity Read

Importance of the Hsp70 ATPase domain in yeast prion propagation.Semantic proximity Read

Coordinated Hsp110 and Hsp104 Activities Power Protein Disaggregation in Saccharomyces cerevisiae.Semantic proximity Read

Propagation of Saccharomyces cerevisiae [PSI+] prion is impaired by factors that regulate Hsp70 substrate binding.Semantic proximity Read

Phosphorylation activates the yeast small heat shock protein Hsp26 by weakening domain contacts in the oligomer ensemble.Semantic proximity Read

Exposed Hsp70-binding site impacts yeast Sup35 prion disaggregation and propagationSemantic proximity Read