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Article

H-Ras mediates the inhibitory effect of epidermal growth factor on the epithelial Na+ channel.

PloS one - 1 Jan 2015

Lee Il-Ha, Song Sung-Hee, Cook David I, Dinudom Anuwat

Abstract excerpt

The present study investigates the role of small G-proteins of the Ras family in the epidermal growth factor (EGF)-activated cellular signalling pathway that downregulates activity of the epithelial Na+ channel (ENaC). We found that H-Ras is a key component of this EGF-activated cellular signalling mechanism in M1 mouse collecting duct cells. Expression of a constitutively active H-Ras mutant inhibited the...

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Source

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Identifiers

PMID: 25774517
DOI: 10.1371/journal.pone.0116938
PMCID: PMC4361710

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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