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Article

The Na+/H+ exchanger regulatory factor stabilizes epidermal growth factor receptors at the cell surface.

Molecular biology of the cell - 1 Dec 2004

Lazar Cheri S, Cresson Catherine M, Lauffenburger Douglas A, Gill Gordon N

Abstract excerpt

Ligand binding to cell surface receptors initiates both signal transduction and endocytosis. Although signaling may continue within the endocytic compartment, down-regulation is the major mechanism that controls the concentration of cell surface receptors, their ability to receive environmental signals, and the ultimate strength of biological signaling. Internalization, recycling, and trafficking of receptor...

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Identifiers

PMID: 15469991
DOI: 10.1091/mbc.e04-03-0239
PMCID: PMC532026

Genes

EGFR
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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