Article
Polygenic load: Earlier disease onset but similar longitudinal progression in Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society - 1 Aug 2018
Lerche Stefanie, Liepelt-Scarfone Inga, Wurster Isabel, Schulte Claudia, Schäffer Eva, Röben Benjamin, Machetanz Gerrit, Zimmermann Milan, Akbas Selda, Hauser Ann-Kathrin, Gasser Thomas, Maetzler Walter, Berg Daniela, Brockmann Kathrin
Abstract excerpt
OBJECTIVES: In order to evaluate the influence of the genetic load of 49 genetic variants known to be associated with PD on the age at onset as well as on clinical outcome parameters. BACKGROUND: PD patients show a large variability in phenotype and progression reflecting interindividual heterogeneity. This might be influenced by a diverse genetic architecture. METHODS: Six hundred seventeen PD patients were...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.