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Article

Innate and adaptive immune traits are differentially affected by genetic and environmental factors.

Nature communications - 5 Jan 2017

Mangino Massimo, Roederer Mario, Beddall Margaret H, Nestle Frank O, Spector Tim D

Abstract excerpt

The diversity and activity of leukocytes is controlled by genetic and environmental influences to maintain balanced immune responses. However, the relative contribution of environmental compared with genetic factors that affect variations in immune traits is unknown. Here we analyse 23,394 immune phenotypes in 497 adult female twins. 76% of these traits show a predominantly heritable influence, whereas 24% are...

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Identifiers

PMID: 28054551
DOI: 10.1038/ncomms13850
PMCID: PMC5227062

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