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Human Adenovirus (HAdV) mediated inhibition of the tumor suppressor p53 is controlled by SUMOylation of the viral E2A/DBP protein

2025-02-08

Abstract excerpt

<h4>ABSTRACT</h4> HAdV express early viral genes to modulate the activity of the cellular tumor suppressor p53 and ensure efficient viral replication, through various processes, whilst some of them are not completely understood. HAdV oncoprotein E1B-55K interactions with SUMO, PML-IV/V and Sp100A are tightly connected to the transforming potential of the viral factor in non-lytic infections. SUMO modified HAdV DN...

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Identifiers and source

Literature Corpus work
0f366b65-a4f7-542d-a493-320b21896794
DOI
10.1101/2025.02.07.636424
Open publication

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Human Adenovirus (HAdV) mediated inhibition of the tumor suppressor p53 is controlled by SUMOylation of the viral E2A/DBP proteinDOI 10.1101/2025.02.07.636424
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