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Article

Distinct requirements of adenovirus E1b55K protein for degradation of cellular substrates.

Journal of virology - 1 Sept 2008

Schwartz Rachel A, Lakdawala Seema S, Eshleman Heather D, Russell Matthew R, Carson Christian T, Weitzman Matthew D

Abstract excerpt

The E1b55K and E4orf6 proteins of adenovirus type 5 (Ad5) assemble into a complex together with cellular proteins including cullin 5, elongins B and C, and Rbx1. This complex possesses E3 ubiquitin ligase activity and targets cellular proteins for proteasome-mediated degradation. The ligase activity has been suggested to be responsible for all functions of E1b55K/E4orf6, including promoting efficient viral DNA...

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Identifiers

PMID: 18614635
DOI: 10.1128/JVI.00925-08
PMCID: PMC2546875

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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