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Article

Cross Talk between PML and p53 during Poliovirus Infection: Implications for Antiviral Defense

15 Aug 2006

Abstract excerpt

PML nuclear bodies (NBs) are dynamic intranuclear structures harboring numerous transiently or permanently localized proteins. PML, the NBs' organizer, is directly induced by interferon, and its expression is critical for antiviral host defense. We describe herein the molecular events following poliovirus infection that lead to PML-dependent p53 activation and protection against virus infection. Poliovirus...

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Identifiers

PMID: 16912307
DOI: 10.1128/jvi.00031-06

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