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Article

The E3 ubiquitin ligase activity associated with the adenoviral E1B-55K-E4orf6 complex does not require CRM1-dependent export.

Journal of virology - 1 Jul 2011

Schmid Melanie, Kindsmüller Kathrin, Wimmer Peter, Groitl Peter, Gonzalez Ramon A, Dobner Thomas

Abstract excerpt

The adenovirus type 5 (Ad5) E1B-55K and E4orf6 (E1B-55K/E4orf6) proteins are multifunctional regulators of Ad5 replication, participating in many processes required for virus growth. A complex containing the two proteins mediates the degradation of cellular proteins through assembly of an E3 ubiquitin ligase and induces shutoff of host cell protein synthesis through selective nucleocytoplasmic viral late mRNA...

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PMID: 21561915
DOI: 10.1128/JVI.02368-10
PMCID: PMC3126608

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The E3 ubiquitin ligase activity associated with the adenoviral E1B-55K-E4orf6 complex does not require CRM1-dependent export.PMID 21561915Read ↗

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