[Study on the association between DNA double-strand break repair gene NBS1 polymorphisms and susceptibility on lung cancer].

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[Study on the association between DNA double-strand break repair gene NBS1 polymorphisms and susceptibility on lung cancer].

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi - 1 Feb 2010

Fan Li-hui, Chen Jun-lei, Cai Lin

Abstract excerpt

OBJECTIVE: To study the association between DNA double-strand break repair gene NBS1 (nijmegen breakage syndrome gene) polymorphisms and the susceptibility to lung cancer. METHODS: A case-control study design was applied. PCR-RFLP was used to identify NBS1 polymorphisms among 575 lung cancer cases and 575 controls. RESULTS: The frequencies of C/C, C/G and G/G genotypes at NBS1 rs1805794 site were 25.9%, 51.8%,...

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PMID: 21215087

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