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Article

Contribution of Double-strand Break Repair Gene Nijmegen Breakage Syndrome 1 Genotypes, Gender Difference and Smoking Status to Taiwanese Lung Cancer.

Anticancer research - 1 May 2017

Chuang Chin-Liang, Wang Chung-Hsing, Hsu Chang-Hsien, Hsiao Chieh-Lun, Chen Guan-Liang, Yen Shiou-Ting, Li Hsin-Ting, Chang Wen-Shin, Tsai Chia-Wen, Wang Shou-Cheng, Bau DA-Tian

Abstract excerpt

BACKGROUND/AIM: Nijmegen breakage syndrome 1 (NBS1) is a component of MRE11/RAD50/NBS1 complex (MRN) that plays a critical role in the cellular response to DNA damage and maintenance of chromosomal integrity. Failure in DNA damage response affects the level of cell survival, increases the frequency of gene mutation or chromosomal instability and other cellular phenotypic abnormalities, which are the important...

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Identifiers

PMID: 28476809
DOI: 10.21873/anticanres.11581

Genes

MRE11
RAD50

Provenance

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