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Article

Association between the NBS1 E185Q polymorphism and cancer risk: a meta-analysis.

BMC cancer - 24 Apr 2009

Lu Meixia, Lu Jiachun, Yang Xiaobo, Yang Miao, Tan Hao, Yun Bai, Shi Luyuan

Abstract excerpt

BACKGROUND: NBS1 is a key DNA repair protein in the homologous recombination repair pathway and a signal modifier in the intra-S phase checkpoint that plays important roles in maintaining genomic stability. The NBS1 8360G>C (Glu185Gln) is one of the most commonly studied polymorphisms of the gene for their association with risk of cancers, but the results are conflicting. METHODS: We performed a meta-analysis...

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Identifiers

PMID: 19393077
DOI: 10.1186/1471-2407-9-124
PMCID: PMC2680905

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