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Article

Functional <i>NBS1</i> polymorphism is associated with occurrence and advanced disease status of nasopharyngeal carcinoma

7 Jun 2011

Abstract excerpt

As a component of the MRN (MRE11/RAD50/NBS1) complex, NBS1 plays an important role in cellular response to DNA damage and the maintenance of chromosomal integrity. The NBS1 E185Q polymorphism (8360G>C, rs1805794) has been frequently studied in some cancers with discordant results, but its association with nasopharyngeal carcinoma (NPC) in Chinese population has not been investigated. Moreover, there is no report...

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PMID: 21656575
DOI: 10.1002/mc.20803

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