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Article

Human glucocorticoid receptor alpha gene (NR3C1) pharmacogenomics: gene resequencing and functional genomics.

The Journal of clinical endocrinology and metabolism - 1 Aug 2009

Niu Nifang, Manickam Venkatraman, Kalari Krishna R, Moon Irene, Pelleymounter Linda L, Eckloff Bruce W, Wieben Eric D, Schaid Daniel J, Wang Liewei

Abstract excerpt

CONTEXT: The human glucocorticoid receptor alpha (GRalpha) is a nuclear hormone receptor that regulates multiple physiological and pathophysiological processes. There are large variations in both physiological and therapeutic response to glucocorticoids. Multiple previous studies suggested that genetic polymorphisms in GRalpha (NR3C1) might play an important role. OBJECTIVE: The aim of the study was to identify...

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Identifiers

PMID: 19435830
DOI: 10.1210/jc.2008-2109
PMCID: PMC2730876

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