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Article

A substitution in the ligand binding domain of the porcine glucocorticoid receptor affects activity of the adrenal gland.

PloS one - 1 Jan 2012

Murani Eduard, Reyer Henry, Ponsuksili Siriluck, Fritschka Stephan, Wimmers Klaus

Abstract excerpt

Glucocorticoids produced in the adrenal cortex under the control of the hypothalamic-pituitary axis play a vital role in the maintenance of basal and stress-related homeostasis and influence health and well-being. To identify loci affecting regulation of the hypothalamic-pituitary-adrenal (HPA) axis in the pig we performed a genome-wide association study for two parameters of acute and long-term adrenal activity:...

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PMID: 23029068
DOI: 10.1371/journal.pone.0045518
PMCID: PMC3445511

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