Article
Novel genetic polymorphisms in the NR3C1 (glucocorticoid receptor) gene in a Japanese population.
Drug metabolism and pharmacokinetics - 1 Feb 2005
Koyano Satoru, Saito Yoshiro, Sai Kimie, Kurose Kouichi, Ozawa Shogo, Nakajima Toshiharu, Matsumoto Kenji, Saito Hirohisa, Shirao Kuniaki, Yoshida Teruhiko, Minami Hironobu, Ohtsu Atsushi, Saijo Nagahiro, Sawada Jun-ichi
Abstract excerpt
Glucocorticoid receptor, encoded by NR3C1, is a transcriptional regulator of many drug metabolizing enzymes and anti-inflammatory molecules. In order to identify genetic variations of the NR3C1 gene, genomic DNA from 265 Japanese individuals was sequenced. Fifty genetic polymorphisms were identified, including 32 novel ones [3 were in coding exons, 17 in the introns, 4 in the 5'-untranslated region (UTR), and 8...
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