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Article

Single nucleotide polymorphisms in the human corticosteroid-binding globulin promoter alter transcriptional activity.

Science China. Life sciences - 1 Aug 2012

Li Yue, Wu Liang, Lei JingHui, Zhu Cheng, Wang HongMei, Yu XiaoGuang, Lin HaiYan

Abstract excerpt

Corticosteroid-binding globulin (CBG) is a high-affinity plasma protein that transports glucocorticoids and progesterone. Others and we have reported non-synonymous single nucleotide polymorphisms (SNPs) that influence CBG production or steroid-binding activity. However, no promoter polymorphisms affecting the transcription of human CBG gene (Cbg) have been reported. In the present study we investigated function...

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PMID: 22932886
DOI: 10.1007/s11427-012-4365-0

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