Article

Hybrid computational modeling highlights reverse Warburg effect in breast cancer-associated fibroblasts

2023-05-14

Abstract excerpt

Cancer-associated fibroblasts (CAFs) are key players of the tumor microenvironment (TME) involved in cancer initiation, progression, and resistance to therapy. These cells exhibit aggressive phenotypes affecting, among others, extracellular matrix remodeling, angiogenesis, immune system modulation, tumor growth, and proliferation. CAFs phenotypic changes appear to be associated with metabolic alterations, notably...

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Literature Corpus work: c579e9da-ab9f-5731-b9ff-674f8ac603e7
DOI: 10.1101/2023.05.11.540378

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