Article

Multiscale Modeling Uncovers Macrophage Infiltration and TNF-α Signaling Networks for Targeting in Inflammatory Breast Cancer Tumor Emboli

2025-06-01

Abstract excerpt

Inflammatory breast cancer (IBC) tumors are characterized by diffuse clusters of cells found in dermal tissue and lymphatic vessels, known as tumor emboli. Thus, IBC needs a novel treatment because it is the most aggressive breast cancer subtype. We hypothesized that the interaction between tumor emboli and the tumor immune microenvironment (TiME) fosters survival signaling, leading to the aggressiveness of the IB...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a612eaac-e11c-5bf1-9f23-fac58aa2cb22
DOI: 10.1101/2025.05.29.656249

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Multiscale Modeling Uncovers Macrophage Infiltration and TNF-α Signaling Networks for Targeting in Inflammatory Breast Cancer Tumor EmboliDOI 10.1101/2025.05.29.656249Read

Tumor emboli-associated adaptive stress response signatures identify aggressive disease features in inflammatory breast cancerSemantic proximity Read

Patient-Specific Vascularized Tumor Model: Blocking TAM Recruitment with Multispecific Antibodies Targeting CCR2 and CSF-1RSemantic proximity Read

Tie2 signaling in the tumor microenvironment orchestrates breast cancer cell dissemination through TMEM doorwaysSemantic proximity Read

Inflammatory Breast Cancer: a model for investigating cluster-based disseminationSemantic proximity Read

Inflammatory breast cancer: a model for investigating cluster-based disseminationSemantic proximity Read

Characterization and Targeting of Platelet-Derived Growth Factor Receptor alpha (PDGFRA) in Inflammatory Breast Cancer (IBC).Semantic proximity Read

CSF-1/CSF-1R axis is associated with epithelial/mesenchymal hybrid phenotype in epithelial-like inflammatory breast cancerSemantic proximity Read

Distinct Endothelial Phenotype Associates with Macrophage-Enriched Microenvironments in Triple-Negative Breast CancerSemantic proximity Read

Gene expression-phenotype association study reveals the dual role of TNF-α/TNFR1 signaling axis in confined breast cancer cell migration.Semantic proximity Read

Geometric Tumor Embolic Budding Characterizes Inflammatory Breast CancerSemantic proximity Read

High endogenous CCL2 expression promotes the aggressive phenotype of human inflammatory breast cancerSemantic proximity Read

Gene expression profiles of inflammatory breast cancer reveal high heterogeneity across the epithelial-hybrid-mesenchymal spectrumSemantic proximity Read