Article

The Inhibition of FGFR/PI3K/Akt Axis by AZD4547 Disrupts the Proangiogenic Microenvironment and Vasculogenic Mimicry Arising from the Interplay between Endothelial and Triple-Negative Breast Cancer Cells

2023-07-18

Abstract excerpt

Vasculogenic mimicry (VM), a process in which aggressive cancer cells form tube-like structures, plays a crucial role in providing nutrients and escape routes. Highly plastic tumor cells, such as those with triple-negative breast cancer (TNBC) phenotype, can develop VM. However, little is known about the interplay between cellular components of the tumor microenvironment upon TNBC cells VM-capacity. In this study,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: eed74fbe-5308-5413-8890-f1b0e71c316e
DOI: 10.20944/preprints202307.1203.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The Inhibition of FGFR/PI3K/Akt Axis by AZD4547 Disrupts the Proangiogenic Microenvironment and Vasculogenic Mimicry Arising from the Interplay between Endothelial and Triple-Negative Breast Cancer CellsDOI 10.20944/preprints202307.1203.v1Read

Vasculogenic Mimicry in Breast Cancer: Clinical Relevance and Drivers.Semantic proximity Read

Epithelial Mesenchymal Transition and Vascular Mimicry in Breast Cancer Stem CellsSemantic proximity Read

Molecular Pathways: Vasculogenic Mimicry in Tumor Cells: Diagnostic and Therapeutic ImplicationsSemantic proximity Read

ErbB4-mediated regulation of vasculogenic mimicry capability in breast cancer cells.Semantic proximity Read

Integrin β1 is an essential factor in vasculogenic mimicry of human cancer cellsSemantic proximity Read

Molecular regulation of vasculogenic mimicry in tumors and potential tumor-target therapySemantic proximity Read

USP44+ Cancer Stem Cell Subclones Contribute to Breast Cancer Aggressiveness by Promoting Vasculogenic Mimicry.Semantic proximity Read

CD133+ cells with cancer stem cell characteristics associates with vasculogenic mimicry in triple-negative breast cancerSemantic proximity Read

Molecular mechanisms of Thrombospondin-2 modulates tumor vasculogenic mimicry by PI3K/AKT/mTOR signaling pathwaySemantic proximity Read

BRCA1 mutation promotes sprouting angiogenesis in inflammatory cancer-associated fibroblast of triple-negative breast cancerSemantic proximity Read

Highly Aggressive and Metastatic MDA-MB-231 and Mel Z Cancer Cells Have Common Sets of Down- and Upregulated Genes During Formation of the Vasculogenic Mimicry Phenotype.Semantic proximity Read

BRCA1 mutation promotes sprouting angiogenesis in inflammatory cancer-associated fibroblast of triple-negative breast cancerSemantic proximity Read