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Article

Mathematical modeling of tumor-associated macrophage interactions with the cancer microenvironment.

Journal for immunotherapy of cancer - 30 Jan 2018

Mahlbacher Grace, Curtis Louis T, Lowengrub John, Frieboes Hermann B

Abstract excerpt

BACKGROUND: Immuno-oncotherapy has emerged as a promising means to target cancer. In particular, therapeutic manipulation of tumor-associated macrophages holds promise due to their various and sometimes opposing roles in tumor progression. It is established that M1-type macrophages suppress tumor progression while M2-types support it. Recently, Tie2-expressing macrophages (TEM) have been identified as a distinct...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29382395
DOI: 10.1186/s40425-017-0313-7
PMCID: PMC5791333

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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