A Co-opted Developmental Gene Regulatory Program in Endothelial Progenitors Promotes Tumor Angiogenic Phenotypes.

doi:10.1158/0008-5472.CAN-25-5094

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Article

A Co-opted Developmental Gene Regulatory Program in Endothelial Progenitors Promotes Tumor Angiogenic Phenotypes.

Cancer research - 2 Sept 2026

Lee Andrew J, Min Sunwoo, Park Su Chan, Qiu Mei-Yu, Bae Jeong Mo, Jin Se Young, Choi Baekgyu, Park Jungin, Kwon So Hyun, Kang Gyeong Hoon, Lee Chul-Hwan, Yang Myung Jin, Park Jihwan, Koh Gou Young, Lee Ji Min, Jung Inkyung

Abstract excerpt

The transition of endothelial cells (EC) to tumor-associated ECs (TEC) is a critical process in tumor progression. The underlying mechanisms driving this angiogenic state could represent potential therapeutic targets. In this study, we revealed that a co-opted gene regulatory program from EC progenitors promotes the angiogenic phenotypes of TECs. Specifically, the TEC-specific gene regulatory program, derived...

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Topics

Humans
Neovascularization, Pathologic
Animals
Tumor Microenvironment
Neoplasms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Cell Differentiation

Mice

Phenotype

Endothelial Progenitor Cells

Gene Expression Regulation, Neoplastic

Endothelial Cells

Integrin alphaV

Cell Movement

Source

Open in PubMed

Identifiers

PMID: 42258673
DOI: 10.1158/0008-5472.CAN-25-5094

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