Selective gene-expression profiling of migratory tumor cells in vivo predicts clinical outcome in breast cancer patients

Abstract excerpt

INTRODUCTION: Metastasis of breast cancer is the main cause of death in patients. Previous genome-wide studies have identified gene-expression patterns correlated with cancer patient outcome. However, these were derived mostly from whole tissue without respect to cell heterogeneity. In reality, only a small subpopulation of invasive cells inside the primary tumor is responsible for escaping and initiating...

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