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Article

Quality control of a transcriptional regulator by SUMO-targeted degradation.

Molecular and cellular biology - 1 Apr 2009

Wang Zheng, Prelich Gregory

Abstract excerpt

Slx5 and Slx8 are heterodimeric RING domain-containing proteins that possess SUMO-targeted ubiquitin ligase (STUbL) activity in vitro. Slx5-Slx8 and its orthologs are proposed to target SUMO conjugates for ubiquitin-mediated proteolysis, but the only in vivo substrate identified to date is mammalian PML, and the physiological importance of SUMO-targeted ubiquitylation remains largely unknown. We previously...

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Source

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Identifiers

PMID: 19139279
DOI: 10.1128/MCB.01470-08
PMCID: PMC2655623

Genes

PML

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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