Dynamic sumoylation is essential in yeast for suppressing stress-induced gene expression in non-stress conditions.

Abstract excerpt

Environmental stresses such as heat shock trigger widespread changes in gene expression, collectively known as the environmental stress response (ESR), along with a global increase in SUMO conjugation. However, whether elevated sumoylation contributes to establishing the ESR gene expression program remains unclear. Here, we show that mutant yeast with constitutively high sumoylation levels due to a defect in the...

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