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Article

Controlling hematopoiesis through sumoylation-dependent regulation of a GATA factor.

Molecular cell - 25 Dec 2009

Lee Hsiang-Ying, Johnson Kirby D, Fujiwara Tohru, Boyer Meghan E, Kim Shin-Il, Bresnick Emery H

Abstract excerpt

GATA factors establish transcriptional networks that control fundamental developmental processes. Whereas the regulator of hematopoiesis GATA-1 is subject to multiple posttranslational modifications, how these modifications influence GATA-1 function at endogenous loci is unknown. We demonstrate that sumoylation of GATA-1 K137 promotes transcriptional activation only at target genes requiring the coregulator...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20064464
DOI: 10.1016/j.molcel.2009.11.005
PMCID: PMC2807411

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