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Article

Genomic Analysis of Single Nucleotide Polymorphisms Asp299Gly and Thr399Ile in Japanese Patients with Invasive Aspergillosis.

Japanese journal of infectious diseases - 1 Jan 2015

Aki Kyoko, Okubo Yoichiro, Nanjo Hiroshi, Ishiwatari Takao, Nihonyanagi Yasuhiro, Tochigi Naobumi, Wakayama Megumi, Nemoto Tetsuo, Fukutake Katsunori, Shinozaki Minoru, Hori Yasuhiro, Masuda Hirotake, Shibuya Kazutoshi

Abstract excerpt

Single nucleotide polymorphisms (SNPs) 1063A/G (Asp299Gly) and 1363C/T (Thr399Ile) in the gene encoding Toll-like receptor 4 (TLR4) increase susceptibility to invasive aspergillosis. However, limited information is available on the prevalence of these SNPs in Japan. Therefore, we surveyed these TLR4 SNPs by using formalin-fixed and paraffin-embedded tissue blocks obtained from autopsies of patients with invasive...

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Identifiers

PMID: 25766605
DOI: 10.7883/yoken.JJID.2014.420

Genes

TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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