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Article

No evidence for involvement of the toll-like receptor (TLR) 4 gene Asp299Gly and Thr399Ile polymorphisms in susceptibility to primary gouty arthritis.

Rheumatology international - 1 Nov 2013

Qing Yu-Feng, Zhou Jing-Guo, Li Ming, Xie Wen-Guang, Huang Cui-Ping, Zeng Sheng-Ping, Yin Ling

Abstract excerpt

Previous studies demonstrated that toll-like receptor (TLR) 4 was involved in the development of autoinflammatory disease including gouty arthritis (GA). TLR4 functional gene Asp299Gly and Thr399Ile polymorphisms play a role in some autoinflammatory disease susceptibility. We undertook this study to analyze the association between the genetic polymorphisms within TLR4 gene and the susceptibility to GA in Chinese...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23152086
DOI: 10.1007/s00296-012-2547-5

Genes

TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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No evidence for involvement of the toll-like receptor (TLR) 4 gene Asp299Gly and Thr399Ile polymorphisms in susceptibility to primary gouty arthritis.PMID 23152086Read ↗

Lack of association of TLR4 gene Asp299Gly and Thr399Ile polymorphisms with rheumatoid arthritis in Chinese Han population of Yunnan Province.Semantic proximity Read ↗

Association of TLR4 Gene rs2149356 polymorphism with primary gouty arthritis in a case-control study.Semantic proximity Read ↗

Association of TLR4 gene non-missense single nucleotide polymorphisms with rheumatoid arthritis in Chinese Han population.Semantic proximity Read ↗

Association of two polymorphisms Asp299Gly and Thr399Ile in Toll-like receptor 4 with rheumatoid arthritis: A meta-analysis.Semantic proximity Read ↗

Analysis of single nucleotide polymorphisms in Toll-like receptor 4 shows no association with ankylosing spondylitis in a Korean population.Semantic proximity Read ↗

The Toll-like receptor 4 Asp299Gly functional variant is associated with decreased rheumatoid arthritis disease susceptibility but does not influence disease severity and/or outcome.Semantic proximity Read ↗

Polymorphisms in the NLRP3 gene and risk of primary gouty arthritis.Semantic proximity Read ↗

Single nucleotide polymorphism of toll-like receptor 4 (TLR4) is associated with juvenile spondyloarthritis in Croatian population.Semantic proximity Read ↗

TLR4 mutations (Asp299Gly and Thr399Ile) are not associated with ankylosing spondylitis.Semantic proximity Read ↗

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Toll-like receptor 4 gene Asp299Gly and Thr399Ile polymorphisms in type 2 diabetes mellitus: a meta-analysis of 15,059 subjects.Semantic proximity Read ↗

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