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Article

Simple genotype analysis of the Asp299Gly polymorphism of the Toll-like receptor-4 gene that is associated with lipopolysaccharide hyporesponsiveness.

Journal of clinical laboratory analysis - 1 Jan 2002

Okayama Naoko, Fujimura Kozue, Suehiro Yutaka, Hamanaka Yuichiro, Fujiwara Motoki, Matsubara Tomoyo, Maekawa Tsuyoshi, Hazama Shoichi, Oka Masaaki, Nohara Hiroaki, Kayano Kozo, Okita Kiwamu, Hinoda Yuji

Abstract excerpt

A nonsynonymous single nucleotide polymorphism (Asp299Gly) in the Toll-like receptor-4 (TLR-4) gene affects the responsiveness to lipopolysaccharide in humans. To analyze this important polymorphism more efficiently, we developed a simple polymerase chain reaction (PCR) restriction length fragmen...

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Identifiers

PMID: 11835533
DOI: 10.1002/jcla.2075
PMCID: PMC6807990

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11835533-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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