Article
Adaptive robust genetic association tests using case-parents triad families.
Biometrical journal. Biometrische Zeitschrift - 1 May 2015
Wang Jiun-Yi, Tai John Jen
Abstract excerpt
Using the conditional likelihood, a model-specific score test can be derived under a given genetic model to test genetic association for case-parents triad family data. When the underlying genetic model is correctly specified, the score test is most powerful. However, it can lose substantial power when the model is misspecified. Several robust tests have been proposed to deal with the problem, such as the maximum...
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