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Article

Generalized functional linear models for gene-based case-control association studies.

Genetic epidemiology - 1 Nov 2014

Fan Ruzong, Wang Yifan, Mills James L, Carter Tonia C, Lobach Iryna, Wilson Alexander F, Bailey-Wilson Joan E, Weeks Daniel E, Xiong Momiao

Abstract excerpt

By using functional data analysis techniques, we developed generalized functional linear models for testing association between a dichotomous trait and multiple genetic variants in a genetic region while adjusting for covariates. Both fixed and mixed effect models are developed and compared. Extensive simulations show that Rao's efficient score tests of the fixed effect models are very conservative since they...

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Identifiers

PMID: 25203683
DOI: 10.1002/gepi.21840
PMCID: PMC4189986

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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