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Article

A role for SNU66 in maintaining 5' splice site identity during spliceosome assembly.

RNA (New York, N.Y.) - 16 May 2024

Sarka Kenna, Katzman Sol, Zahler Alan M

Abstract excerpt

In spliceosome assembly, the 5' splice site is initially recognized by U1 snRNA. U1 leaves the spliceosome during the assembly process, therefore other factors contribute to the maintenance of 5' splice site identity as it is loaded into the catalytic site. Recent structural data suggest that human tri-snRNP 27K (SNRP27) M141 and SNU66 H734 interact to stabilize the U4/U6 quasi-pseudo knot at the base of the U6...

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Identifiers

PMID: 38443114
DOI: 10.1261/rna.079971.124
PMCID: PMC11098459

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A role for SNU66 in maintaining 5' splice site identity during spliceosome assembly.PMID 38443114Read ↗

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