Article
Multiple mechanisms of MYCN dysregulation in Wilms tumour.
Oncotarget - 30 Mar 2015
Williams Richard D, Chagtai Tasnim, Alcaide-German Marisa, Apps John, Wegert Jenny, Popov Sergey, Vujanic Gordan, van Tinteren Harm, van den Heuvel-Eibrink Marry M, Kool Marcel, de Kraker Jan, Gisselsson David, Graf Norbert, Gessler Manfred, Pritchard-Jones Kathy
Abstract excerpt
Genomic gain of the proto-oncogene transcription factor gene MYCN is associated with poor prognosis in several childhood cancers. Here we present a comprehensive copy number analysis of MYCN in Wilms tumour (WT), demonstrating that gain of this gene is associated with anaplasia and with poorer relapse-free and overall survival, independent of histology. Using whole exome and gene-specific sequencing, together...
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