Article
Clinically and biologically relevant subgroups of Wilms tumour defined by genomic and epigenomic analyses.
British journal of cancer - 1 Jan 2021
Brzezinski Jack, Choufani Sanaa, Romao Rodrigo, Shuman Cheryl, Chen Haiying, Cunanan Joanna, Bagli Darius, Grant Ronald, Lorenzo Armando, Weksberg Rosanna
Abstract excerpt
BACKGROUND: Although cure rates for Wilms tumours (WT) are high, many patients receive therapy with attendant long-term complications. Our goal was to stratify WT using genome-wide analyses to identify candidate molecular features for patients who would benefit from a reduction in therapy. METHODS: We generated DNA methylation and exome sequencing data on WT-kidney pairs (n = 57) and unpaired tumours (n = 27)...
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