Article

Transcriptomic analyses of MYCN-regulated genes in anaplastic Wilms’ tumour cell lines reveals oncogenic pathways and potential therapeutic vulnerabilities

2021-01-11

Abstract excerpt

The MYCN proto-oncogene is deregulated in many cancers, most notably in neuroblastoma where MYCN gene amplification identifies a clinical subset with very poor prognosis. Gene expression and DNA analyses have also demonstrated over-expression of MYCN mRNA, as well as focal amplifications, copy number gains and presumptive change of function mutations of MYCN in Wilms’ tumours with poorer outcome, including tum...

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Literature Corpus work: b03c6c83-be6d-5264-b99f-6ef7465c4108
DOI: 10.1101/2021.01.11.426177

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