Article
Distinct pathways for genetic and epigenetic predisposition in familial and bilateral Wilms tumor.
Genome medicine - 8 May 2025
Wegert Jenny, Appenzeller Silke, Treger Taryn D, Streitenberger Heike, Ziegler Barbara, Bausenwein Sabrina, Vokuhl Christian, Parks Conor, Jüttner Eva, Gramlich Susanne, Ernestus Karen, Warman Steven W, Fuchs Jörg, Hubertus Jochen, von Schweinitz Dietrich, Fröhlich Birgit, Jorch Norbert, Knöfler Ralf, Friedrich Carsten, Corbacioglu Selim, Frühwald Michael C, Pekrun Arnulf, Schneider Dominik T, Faber Jörg, Stursberg Jana, Metzler Markus, Welter Nils, Pritchard-Jones Kathy, Graf Norbert, Furtwängler Rhoikos, Behjati Sam, Gessler Manfred
Abstract excerpt
BACKGROUND: Genetic predisposition is particularly common in children with the kidney cancer, Wilms tumor. In 10% of these children, this manifests as a family history of Wilms tumor or bilateral disease. The frequency and spectrum of underlying changes have not been systematically investigated. METHODS: We analyzed 129 children with suspected Wilms tumor predisposition, 20 familial cases, and 109 children with...
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