Article
Genetic and epigenetic features of bilateral Wilms tumor predisposition in patients from the Children's Oncology Group AREN18B5-Q.
Nature communications - 18 Dec 2023
Murphy Andrew J, Cheng Changde, Williams Justin, Shaw Timothy I, Pinto Emilia M, Dieseldorff-Jones Karissa, Brzezinski Jack, Renfro Lindsay A, Tornwall Brett, Huff Vicki, Hong Andrew L, Mullen Elizabeth A, Crompton Brian, Dome Jeffrey S, Fernandez Conrad V, Geller James I, Ehrlich Peter F, Mulder Heather, Oak Ninad, Maciezsek Jamie, Jablonowski Carolyn M, Fleming Andrew M, Pichavaram Prahalathan, Morton Christopher L, Easton John, Nichols Kim E, Clay Michael R, Santiago Teresa, Zhang Jinghui, Yang Jun, Zambetti Gerard P, Wang Zhaoming, Davidoff Andrew M, Chen Xiang
Abstract excerpt
Developing synchronous bilateral Wilms tumor suggests an underlying (epi)genetic predisposition. Here, we evaluate this predisposition in 68 patients using whole exome or genome sequencing (n = 85 tumors from 61 patients with matched germline blood DNA), RNA-seq (n = 99 tumors), and DNA methylation analysis (n = 61 peripheral blood, n = 29 non-diseased kidney, n = 99 tumors). We determine the predominant events...
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