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Article

Synchronous bilateral Wilms tumors are prone to develop independently and respond differently to preoperative chemotherapy.

International journal of cancer - 1 May 2025

Tao Ting, Liu Shuangai, He Min, Zhao Manli, Chen Chen, Peng Jinkai, Wang Yilong, Cai Jiabin, Xiong Jieni, Lai Can, Gu Weizhong, Ying Meidan, Mao Junqing, Li Linjie, Jia Xuan, Wu Xuan, Peng Wanxin, Zhang Xiang, Li Yong, Li Tao, Wang Jinhu, Shu Qiang

Abstract excerpt

Wilms tumor (WT) is the most common kidney cancer in infants and young children. The determination of the clonality of bilateral WTs is critical to the treatment, because lineage-independent and metastatic tumors may require different treatment strategies. Here we found synchronous bilateral WT (n = 24 tumors from 12 patients) responded differently to preoperative chemotherapy. Transcriptome, whole-exome and...

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Antineoplastic Combined Chemotherapy Protocols
beta Catenin
Exome Sequencing
Kidney Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Loss of Heterozygosity

Neoplasms, Multiple Primary

Source

Identifiers

PMID: 39723643
DOI: 10.1002/ijc.35297

Genes

CTNNB1
WT1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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