Article
Link between embryonic stem cell pluripotency and homologous allelic pairing of Oct4 loci.
Development, growth & differentiation - 1 Oct 2017
Asaka Masamitsu N, Uranishi Kousuke, Suzuki Ayumu, Hirasaki Masataka, Nishimoto Masazumi, Okuda Akihiko
Abstract excerpt
The Oct4 gene is a master regulator of the pluripotent properties of embryonic stem cells (ESCs). Recently, Oct4 loci were shown to frequently localize in close proximity to one another during the early stage of cellular differentiation, implicating this event as an important prerequisite step for ESCs to exert their full differentiation potential. Although the differentiation capacity of embryonal carcinoma...
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