Interchromosomal interaction of homologous Stat92E alleles regulates transcriptional switch during stem-cell differentiation.

doi:10.1038/s41467-022-31737-y

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Article

Interchromosomal interaction of homologous Stat92E alleles regulates transcriptional switch during stem-cell differentiation.

Nature communications - 9 Jul 2022

Antel Matthew, Raj Romir, Masoud Madona Y G, Pan Ziwei, Li Sheng, Mellone Barbara G, Inaba Mayu

Abstract excerpt

Pairing of homologous chromosomes in somatic cells provides the opportunity of interchromosomal interaction between homologous gene regions. In the Drosophila male germline, the Stat92E gene is highly expressed in a germline stem cell (GSC) and gradually downregulated during the differentiation. Here we show that the pairing of Stat92E is always tight in GSCs and immediately loosened in differentiating daughter...

Topics

Alleles
Animals
Cell Differentiation
Drosophila
Drosophila Proteins
Drosophila melanogaster
Germ Cells

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Identifiers

PMID: 35810185
DOI: 10.1038/s41467-022-31737-y
PMCID: PMC9271046

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